Simulation of Na channel inactivation by thiazine dyes.
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Simulation of Na channel inactivation by thiazine dyes
Some dyes of the methylene blue family serve as artificial inactivators of the sodium channels when present inside squid axons at a concentration of approximately 0.1 mM. The dyes restore a semblance of inactivation after normal inactivation has been destroyed by pronase. In fibers that inactivate normally, the dyes hasten the decay of sodium current. Many dye-blocked channels conduct transient...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1982
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.80.5.641